CIPHUR (Chlorhexidine vs Iodine Prep in Hand sURgery)
A multicentre prospective cohort study evaluating different antiseptic skin preparation solutions before upper-limb surgery surgeons.org. CIPHUR involved 42 hospitals and 2,454 patients, making it one of the largest collaborative audits in hand surgery infection prevention.
Key Findings
The use of alcoholic chlorhexidine for preoperative skin antisepsis reduced the risk of surgical site infection by ~70% compared to povidone-iodine solutions. This is a striking outcome that has influenced infection control practices – the findings were published in BJS Open in late 2021 pubmed.ncbi.nlm.nih.govresearch-repository.uwa.edu.au and have been adopted as evidence in hand surgery protocols worldwide. The CIPHUR study also demonstrated the power of global collaboration: it included contributors from Australia, New Zealand, and multiple international sites, all credited under a collaborative authorship model.